High-throughput IR-FRS for intensive-care medicine



Prof. Michael Bauer (left), director of the Department of Anaestehesiology and Intensive care Medicine at Jena University Hospital, and Prof. Ioachim Pupeza (right), head of the Laboratory for Lightwave Metrology, at the 36th German Symposium for Intensive Care Medicine.

Infrared field-resolved spectroscopy (IR-FRS) has a unique potential of acquiring quantitative molecular fingerprints from biological samples such as cells or gases in a fast, label-free manner – while covering the entire physiologically relevant molecular concentration range. In a close collaboration with the Department of Anaestehesiology and Intensive care Medicine at Jena University Hospital (Prof. Michael Bauer), at the Laboratory of Lightwave Metrology, we are preparing the first application of IR-FRS at an intensive-care unit (ICU). The grand vision is to draw from the uniquely fast sampling time of IR-FRS to guide therapy by real-time diagnostics (“theranostics”).

Combining cutting-edge research in the fields of laser physics and spectroscopy with exploring new routes in medicine is a highly ambitious, multi-disciplinary endeavor. We are all the more excited to announce the support of our research group at Leibniz-IPHT in Jena by the Thüringer Aufbaubank with an instrumentation grant exceeding 500,000.00 €, allowing our group to purchase the laser frontend for building a compact, user-friendly fiber-based FRS system of the next generation, for bedside spectroscopic analysis of exhaled breath and label-free flow cytometry.